Cytotoxic brain tissue edema is the result of uncontrolled intracellular swelling as a secondary complication to trauma, stroke or in some brain tumours. Different clinical treatments have seen the light although unsuccessful in effectiveness. One of the reasons is probably the lack of knowledge to its etiology. The present book is dealing with a theory where a new hypothesis on the etiology to cytotoxic brain tissue edema is outlined. Based on research focusing on computerized simulation and laboratory investigation and their results, it is suggested that the cytotoxic edema is caused by a disruption of mature protein structures which aims to overcome the negative effect from the dynamic Triple Peak Impact Factor. The search for similarities in the nature like the white shark metabolism, a new hypothesis is suggested that cytotoxic brain tissue edema should be looked upon as a defence mechanism to regain normal cellular metabolism following traumatic brain injury, stroke or in some brain tumours. If this new hypothesis makes it possible to understand the etiology, it should be possible to find alternative and successful treatment to cytotoxic brain tissue edema.