With Spain now united, Ferdinand looked to his daughters to further his ambitions. All too often, Isabella found herself torn between his brilliant plans and her love for her children. During the last years of Isabella's reign it seemed there was a curse on the royal house which struck at the children of the sovereigns. Tragedy followed tragedy - the Infanta Isabella, a broken-hearted widow; Juana, driven to madness by her husband's philandering; and the sorrow of parting with young Catalina, destined to become Katharine of Aragon, wife to Henry VIII and Queen of England.